Research

 

ME RESEARCH

The UK based ME Association has published a wonderful comprehensive Index of Published ME Research. This online publication is an extraordinary resource, broken up into categories ranging from nomenclature and definition to research by subject.

#MEAction's Director of Scientific and Medical Outreach, Jaime Selzer, has put together #MEAction's 2019 ME Research Summary by Jaime Selzer

Following are our own ME Research Highlights.

 

Conferences: Videos and Reports

NIH 2-day Conference, April 2019

There have been major advances in understanding, but unfortunately, not yet treating, Myalgic Encephalomyelitis. Read this report in JAMA on the April 2019 2-day NIH conference, Accelerating Research on Myalgic Encephalomyelitis / Chronic Fatigue Syndrome.

Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome

Anthony L. Komaroff, MD1, JAMA. Published online July 5, 2019. doi:10.1001/jama.2019.8312

OMF-sponsored 3rd Annual Community Symposium on the Molecular Basis of ME/CFS at Stanford University, 7 September 2019. The individual talks from the Symposium are now available as separate videos in a playlist on OMF's YouTube channel.  You can find the Agenda here.

UK CFS/M.E. Research Collaborative (CMRC) fifth annual science conference, 19 and 20 September 2018, Bristol

Videos from the conference available thanks to Action for ME

13th Invest in ME Research International ME Conference, 1 June 2018
Conference Report: http://www.investinme.eu/IIMEC13.shtml

 

Microbiome

 

Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (Dr Maureen Hanson)

 

Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome


 

Immune signature, cytokines, antibodies

 

Distinct plasma immune signatures in ME/CFS are present early in the course of illness

 

Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome

 

Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology (Jarred Younger)

 

Deficient EBV-Specific B- and T-Cell Response in Patients with Chronic Fatigue Syndrome

 

Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome

 

Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology


 

Metabolomics

 

Metabolic features of chronic fatigue syndrome (Dr Naviaux)

 

Metabolic features of the cell danger response (Dr Naviaux)

 

Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients (Chris Armstrong)

 

NMR metabolic profiling of serum identifies amino acid disturbances in chronic fatigue syndrome (Chris Armstrong)

 

The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome

 

Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome (Dr Fluge, Dr Mella)

 

Researchers find distinct molecular signatures in chronic fatigue syndrome and Gulf War Illness (Nov 2017)


 

Brain Studies

 

Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

 

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study

 

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study


 

Right arcuate Fasciculus abnormality in chronic Fatigue syndrome

 

qEEG / LORETA in Assessment of Neurocognitive Impairment in a Patient with Chronic Fatigue Syndrome: A Case Report

 

Intrinsic Functional Hypoconnectivity in Core Neurocognitive Networks Suggests Central Nervous System Pathology in Patients with Myalgic Encephalomyelitis: A Pilot Study


 

Epigenetics

Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Santiago Herrara, Wilfred C. de Vega, David Ashbrook, Suzanne D. Vernon & Patrick O. McGowan, Journal of Epigenetics, 5 December, 2018.

This study is a U.S.- Canadian collaboration. 

Epidemiology

 

Differentiating Multiple Sclerosis from Myalgic Encephalomyelitis and Chronic Fatigue Syndrome (Dr Jason)

 

Subtyping patients with myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) by course of illness (Dr Jason)


 

Dr Ron Davis

 

Open Medicine Foundation

 

The puzzle solver: A researcher changes course to help his son (magazine article)

 

Dr Ron Davis updates us on current research, May 2018 (video)

 

Scientist Ron Davis Tells How We Are "Fast-Tracking" ME/CFS Research (video)

 

 

General Articles and Videos

How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies? Great article by Dr. Luis Nacul.

Links to all articles related to ME/CFS that have been published at virology blog, and episodes of the science show This Week in Virology

Exercise Intolerance from ParadigmChange.me

 

Janet Dafoe, an ME/CFS Caregiver, Speaks about Living with the Disease

The risk of suicide among ME/CFS patients is a staggering five times higher than the general population. Read this Spanish study.

 

Tired of explaining ME/CFS?  Report By Healthwatch-Trafford

 

FIBROMYALGIA RESEARCH

The UK based ME Association has published a wonderful comprehensive Index of Published ME Research which includes research articles on fibromyalgia. This online publication is an extraordinary resource, broken up into categories ranging from nomenclature and definition to research by subject.

Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation, Daniel Albrecht, PhD, MGH Martinos Center and Department of Radiology, and Anton Forsberg, PhD, Karolinska Institutet, Brain Behaviour and Immunity, 14 September 2018

This study by Massachusetts General Hospital (MGH) researchers documents widespread inflammation in the brains of patients with  fibromyalgia. 

Systematic analysis of the cerebrospinal fluid proteome of fibromyalgia patients, Journal of Proteomics, Volume 190, 6 January 2019, 35-43

New study identifies 4 proteins involved in inflammation, metabolism and neuropeptide production found at abnormal levels in the cerebral spinal fluid of fibromyalgia patients

Longitudinal stability of fibromyalgia symptom clusters, Tanya L. Hoskin, Mary O. Whipple, et al., Arthritis Resaruc & therapy, 2018, 20:37

Fibromyalgia patients classified into four unique symptom clusters based on the key domains of pain, fatigue, sleep disturbance, function, stiffness, dyscognition, depression, and anxiety showed moderate stability in cluster assignment after 2 years. Few patients moved between the two extremes of severity, and it was slightly more common to move to a lower symptom level than to worsen.

Kathryn Zador of Kitchener received a Sovereign's Medal for founding FibroMoves, an in-pool rehabilitation program to help people who suffer from fibromyalgia (FM), 9 March 2018, TheRecord.com

A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia, William L. Pridgen, et al., J Pain Res. 2017; 10: 451–460.

Conclusion: IMC-1 was efficacious and safe in treating symptoms of fibromyalgia, supporting the hypothesis that herpes virus infections may contribute to this syndrome. Improved retention rates, decreased adverse event rates, and evidence of efficacy on a broad spectrum of outcome measures are suggestive that IMC-1 may represent an effective, novel treatment for fibromyalgia.

Through the “Valley of Death”: Dr. Pridgen, Fibromyalgia and the Looming Trials, Cort Johnson , Simmaron Research, March 26, 2017

Recent Articles by National Pain Reporthttp://nationalpainreport.com/category/fibromyalgia

  • 10 Reasons to Fire Your Fibromyalgia Doctor

  • Trial Shows Positive Results for Treatment for Fibromyalgia

  • Green Light LED Being Tested to Treat Chronic Pain and Fibromyalgia

  • 6 Gadgets to Help Relieve Fibromyalgia Pain

  • 9 Tips For Anyone Newly Diagnosed with Fibromyalgia

  • A Year in Review: 2016’s Top Fibromyalgia Stories

Dry Eye Syndrome Risks in Patients With Fibromyalgia: A National Retrospective Cohort StudyChao-Hsien Chen, PhD, Tse-Yen Yang, PhD, Medicine (Baltimore). 2016 Jan; 95(4): e2607

FM patients have a higher incidence of dry eye syndrom (DES) than that of non-FM patients. They carry long-term DES risks from a relatively young age, particularly those with psychiatric problems. Risk stratification for a timely psychiatric medication intervention and risk modifications are not intended.

Meta-analysis of cognitive performance in fibromyalgia, Jarred Younger, et al.,  Journal of Clinical and Experimental Neuropsychology , Vol. 40, 2018, Issue 7

Conclusion: These findings support the hypothesis that the self-reported cognitive impact of fibromyalgia is also found in objective neuropsychological measures. Routine screening for cognitive dysfunction in those with fibromyalgia may be warranted in addition to assessment of the traditional fibromyalgia symptoms.

 

ME & FIBROMYALGIA RESEARCH

A Doctor with Chronic Illness By Amy Stenehjem, M.D

 

Grief and Chronic Illness not part of the care plan

 
 
 

RESEARCH NEWS

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