The UK based ME Association has published a wonderful comprehensive Index of Published ME Research. This online publication is an extraordinary resource, broken up into categories ranging from nomenclature and definition to research by subject.
#MEAction's Director of Scientific and Medical Outreach, Jaime Selzer, has put together #MEAction's 2019 ME Research Summary
Following are our own ME Research Highlights.
Conferences: Videos and Reports
NIH 2-day Conference, April 2019
There have been major advances in understanding, but unfortunately, not yet treating, Myalgic Encephalomyelitis. Read this report in JAMA on the April 2019 2-day NIH conference, Accelerating Research on Myalgic Encephalomyelitis / Chronic Fatigue Syndrome.
Anthony L. Komaroff, MD1, JAMA. Published online July 5, 2019. doi:10.1001/jama.2019.8312
OMF-sponsored 3rd Annual Community Symposium on the Molecular Basis of ME/CFS at Stanford University, 7 September 2019. The individual talks from the Symposium are now available as separate videos in a playlist on OMF's YouTube channel. You can find the Agenda here.
UK CFS/M.E. Research Collaborative (CMRC) fifth annual science conference, 19 and 20 September 2018, Bristol
13th Invest in ME Research International ME Conference, 1 June 2018
Conference Report: http://www.investinme.eu/IIMEC13.shtml
Immune signature, cytokines, antibodies
Metabolic features of chronic fatigue syndrome (Dr Naviaux)
Metabolic features of the cell danger response (Dr Naviaux)
Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Santiago Herrara, Wilfred C. de Vega, David Ashbrook, Suzanne D. Vernon & Patrick O. McGowan, Journal of Epigenetics, 5 December, 2018.
This study is a U.S.- Canadian collaboration.
Dr Ron Davis
The puzzle solver: A researcher changes course to help his son (magazine article)
General Articles and Videos
How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies? Great article by Dr. Luis Nacul.
Links to all articles related to ME/CFS that have been published at virology blog, and episodes of the science show This Week in Virology
Exercise Intolerance from ParadigmChange.me
Janet Dafoe, an ME/CFS Caregiver, Speaks about Living with the Disease
The risk of suicide among ME/CFS patients is a staggering five times higher than the general population. Read this Spanish study.
Tired of explaining ME/CFS? Report By Healthwatch-Trafford
The UK based ME Association has published a wonderful comprehensive Index of Published ME Research, which includes research articles on fibromyalgia. This online publication is an extraordinary resource, broken up into categories ranging from nomenclature and definition to research by subject.
Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation, Daniel Albrecht, PhD, MGH Martinos Center and Department of Radiology, and Anton Forsberg, PhD, Karolinska Institutet, Brain Behaviour and Immunity, 14 September 2018
This study by Massachusetts General Hospital (MGH) researchers documents widespread inflammation in the brains of patients with fibromyalgia.
Systematic analysis of the cerebrospinal fluid proteome of fibromyalgia patients, Journal of Proteomics, Volume 190, 6 January 2019, 35-43
New study identifies 4 proteins involved in inflammation, metabolism and neuropeptide production found at abnormal levels in the cerebral spinal fluid of fibromyalgia patients
Longitudinal stability of fibromyalgia symptom clusters, Tanya L. Hoskin, Mary O. Whipple, et al., Arthritis Resaruc & therapy, 2018, 20:37
Fibromyalgia patients classified into four unique symptom clusters based on the key domains of pain, fatigue, sleep disturbance, function, stiffness, dyscognition, depression, and anxiety showed moderate stability in cluster assignment after 2 years. Few patients moved between the two extremes of severity, and it was slightly more common to move to a lower symptom level than to worsen.
A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia, William L. Pridgen, et al., J Pain Res. 2017; 10: 451–460.
Conclusion: IMC-1 was efficacious and safe in treating symptoms of fibromyalgia, supporting the hypothesis that herpes virus infections may contribute to this syndrome. Improved retention rates, decreased adverse event rates, and evidence of efficacy on a broad spectrum of outcome measures are suggestive that IMC-1 may represent an effective, novel treatment for fibromyalgia.
Through the “Valley of Death”: Dr. Pridgen, Fibromyalgia and the Looming Trials, Cort Johnson , Simmaron Research, March 26, 2017
Recent Articles by National Pain Report: http://nationalpainreport.com/category/fibromyalgia
10 Reasons to Fire Your Fibromyalgia Doctor
Trial Shows Positive Results for Treatment for Fibromyalgia
Green Light LED Being Tested to Treat Chronic Pain and Fibromyalgia
6 Gadgets to Help Relieve Fibromyalgia Pain
9 Tips For Anyone Newly Diagnosed with Fibromyalgia
A Year in Review: 2016’s Top Fibromyalgia Stories
Dry Eye Syndrome Risks in Patients With Fibromyalgia: A National Retrospective Cohort Study, Chao-Hsien Chen, PhD, Tse-Yen Yang, PhD, Medicine (Baltimore). 2016 Jan; 95(4): e2607
FM patients have a higher incidence of dry eye syndrom (DES) than that of non-FM patients. They carry long-term DES risks from a relatively young age, particularly those with psychiatric problems. Risk stratification for a timely psychiatric medication intervention and risk modifications are not intended.
Conclusion: These findings support the hypothesis that the self-reported cognitive impact of fibromyalgia is also found in objective neuropsychological measures. Routine screening for cognitive dysfunction in those with fibromyalgia may be warranted in addition to assessment of the traditional fibromyalgia symptoms.
ME & FIBROMYALGIA RESEARCH
A Doctor with Chronic Illness By Amy Stenehjem, M.D