

Types of Long-COVID
The term "Long-COVID" often causes confusion as it can refer to three distinct and different outcomes of COVID-19 infection: Organ and tissue damage caused by the virus; the extended recovery time from the initial infection experienced by some patients; and the development of Myalgic Encephalomyelitis (ME), a complex chronic illness triggered in some by COVID-19.

Organ and tissue damage


Extended recovery time
Recovery from COVID-19 varies greatly among individuals:
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Mild cases may recover within 1-2 weeks5
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Severe cases can take 6 weeks or longer to recover5
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Some individuals experience symptoms lasting for months2
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Recent research suggests that COVID-19 may linger in the body for 14 months to two years after infection, even after symptoms subside.2
Post-viral illnesses
For some patients, what their doctor has diagnosed as “Long-COVID” shares many symptoms with Myalgic Encephalomyelitis (ME) (ref). ME can be triggered by various pathogens, including Epstein-Barr virus, Coxiella burnetii, and SARS-CoV-2 (the virus underlying COVID-19) (ref).
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When Long-COVID persists and meets ME diagnostic criteria, it is essentially ME (ref). Recent studies show a significant overlap between this type of Long-COVID diagnosis and an ME diagnosis after COVID-19, with 89% of post-COVID ME cases also meeting Long-COVID criteria (ref, ref2).

Common symptoms of Long-COVID/ME include:
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Fatigue
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Cognitive impairment ("brain fog")
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When triggered by COVID-19, symptoms may also include persistent cough and lung issues
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Autonomic dysfunction
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Post-exertional malaise (an immediate or delayed, sometimes severe, worsening of symptoms that may occur even after minimal physical, emotional, cognitive or sensory exertion).
Each of these outcomes has different implications for patient care and recovery, making it important to distinguish between them when discussing the long-term impacts of COVID-19.